Starting Off on the Right Foot
This guide assumes that you have some familiarity with Guild Wars and its different short cut keys. If you do not, I suggest you start by looking at your options in the menu, look at the bottom of the option page for control setup under game options.
After creating your character, the game will take you to a beautiful area. The game foreshadows that this time of innocence will soon past. With this means to you, as a player, is that this area is temporary. You should therefore do what you have to do before moving on. You will notice some characters have exclamation marks over their heads. Yes, they are happy to see you but they also have a quest for you. Mosey over to them to find out what they have to say. Most of the quests are optional but some have more value than others. These things should be on your checklist:
Grab all the skills for your primary profession. You can get skills from different trainers for your main profession. The first set is always right outside the city gates and you will get directions to the other ones provided you read what the NPCs (non-player characters) have to say. You don't have to get skills if you don't want to but you will have a hard time without them. These skills are also 'free' and if you want to get them later, you will have to pay for them with gold, as well as skill points. You get 1 skill point per level up, each time you complete a mission for the first time (as that character) and for each new fame rank you gain. Fame is something you accumulate in the Tombs of Primeval kings. You get fame for beating the other team(s) in various PVP (player versus player) maps. You can sometimes get skill points from quests too.
Get a secondary profession. This is optional but recommended. If you like the aesthetics of only having one profession, you can skip this step. However, keep in mind that there are no advantages to only having one profession at this time and some players might view your character as more limited than other ones. You can get another profession by running into various NPCs as you travel. You can also take the more direct route by asking some NPCs for directions. Once you have chosen a secondary profession, you can not change it for a long time. Therefore, if you are someone who likes to experience as much as possible, leave the 'newbie' area with as much experience as possible, or want to eventually unlock all the skills, weapon upgrades, and armour upgrades (more on this later), you will want to do all the second profession quests before making your 'permanent' choice. If you are new to the game, this is also recommended. If you are in a hurry to get to the rest of the game, go straight to trainer you want, do the quests and accept the second profession. There are more than one skill trainers for secondary professions. It is recommended you visit all of them.
Grab the Signet of Resurrection. All you have to do is leave the city in a group of 2, talk to the monk outside, and you have the signet. The signet is a limited resurrection skill but will come in handy if ever you should find yourself with someone in your party dead and no one alive is part monk. Or if the monk does not have resurrection. This skill is a life saver in long, hard mission.
Grab a belt pouch. You can get one for 5 fins or for 5 worn pouches. If you plan on staying in the tutorial area of the game for a long time, you will eventually get 5 fins or 5 pouches. Especially on your way to Fort Ranik. If you are in a hurry to leave at level 3, you can continuously kill the skale monsters near Ascalon, leave, and repeat. It is boring and gives you a view of what playing a standard MMORPG is like but if that's what you want to do, then so be it. If you do everything there is to do for your character in the tutorial area, you will spend roughly 5 hours there. This will also take you to level 7 or so, at which point staying here longer is counter productive. Monsters give less experience as your level goes up so you will eventually have to leave for greener pastures. Once you decide you are ready to move on, be it at level 3 (the minimum) or level 7+, go talk to Tydus to enter the academy. This mission will give you a taste of what PVP is like in the game as well as what a 'mission' is. You win the academy by killing more of the enemy than they kill of you. Each time someone dies, they resurrect at the back and the team responsible for the kill gains a point. You should be evenly matched regardless of your level. If you are high level, your team might be smaller than the other team. If there are not enough players, henchmen might join. These are computer controlled combatants. If there is no one at all doing this at the same time as you, you skip the PVP part. Once time is up, the team with the most points win and you move on to the mission. After the mission, which is easy, you will find yourself in a world that has changed.
Cities provide a variety of services. Some provide more than others. In cities, you can:
Buy a salvage kit for 100 gold (if you have that much, if not, consider exploring the wilderness as discussed in another choice further down). This will allow you to make room in your inventory mid mission. This is because 10 swords take 10 inventory spaces, but the iron salvaged from those 10 swords takes 1 space. This is important, as you will soon find out, as not being able to pick up anything slows your profit or yourself, if you choose to make room by dropping something else first. Salvaging usually ends up costing you money. This is because the price of most raw materials is the same price as an unsalvaged weapon, or less. Salvage kits (or any kit for that matter) always sell back to NPCs for half the price, regardless of how many uses they have. Since the developers show no sign of wanting to change this, use this to your advantage by using 24 out of the 25 charges and then selling the kit with one charge left for 50 gold. The kits in pre-searing ascalon cost less but have less uses.
Expert Kits. These cost more than regular kits but can also yield more material from an item or give you a special upgrade you can transfer to another weapon. These kits are found in Yak's bend or more advanced cities. These upgrades are typically found on items with suffixes. For example a 'longbow of poisoning' will usually give you a string to increase the length of poison skills. You can apply this string to other weapons, like another bow that does more damage for example. Runes are found off green, yellow or blue tinted monster armour. This colour designates if an item is "magic" 'rare' or 'unique'. "Magic" just means the item adds something minor. Rare means the item has more modifiers than usual and usually does higher damage than it should for the area it was found in. Blue means the properties are not randomly determined. For armour, which has no stats, this determines how much material you will get and the likelihood of finding a rune as well as the level of the rune.
Buy an Identification kit. These kits let you know what enchantments are present on your equipment when these items have the 'unknown' property. Using these kits also 'Unlocks' weapon and armour upgrades if the right ones are found on the weapon. What this means if that if you should ever decide to make a premade level 20 PVP character, you can add these upgrades to the equipment of these characters. If you like mystery in your items, have no intention of ever using premades, or don't feel like a collector, you can ignore ID kits. Items sometime sell for more to NPCS if they are Identified, but the effect will still be there, and if salvaging the item would net a certain upgrade or material, it will still be salvaged. This can also help you decide if you want to use the more expensive expert salvage kit on an item. You don't need an ID kit until you start seeing coloured armour from my experience as the weapons before that don't seem to provide any grips, handles and what not.
Join a guild. Regardless of your long term expectations, joining a guild right away has the following benefits: you can ask them for help with skills or the game and you can play with a guild group. Guild groups are useful because you can adapt your skill bar to how they play easier since you will likely play with them more often than a random person in a pick up group. This can make your life easier as you know what to expect. They may also have player monks in the guild and player monks aren't easy to find. If you find that the guild does not suit you for whatever reason like you want to do PVP and they do not, you can leave as easily as you joined it. Guild hopping at low levels or when you are just starting doesn't hurt your online reputation much if at all. Just don't sabotage or yell at the guild; instead, just leave. To join guilds, the invitation can be found in 'guild' on the menu, and to leave the guild, click on yourself in the guild member list and choose leave guild. Guilds are plentiful so you are bound to find one you like.
Buy some skills. You will probably not be comfortable with the menagerie of skills you will get in the intro area; there is bound to be a skill or two you do not use. This is especially the case if you picked warrior, as the different trainers give skills that must be used with a different specific weapon. You might also want to focus on fewer attributes than your current skill set allows you. You can start to buy skills after the academy although the first time you will see skills that can not be gained by questing is at Grendich Courthouse, which is an optional area. If the settlement allows you to buy capture signets, you have a choice. Buying skills gets progressively more expensive each time you acquire a skill. Capture signets are half the price but you need to find a boss of the right profession to try to steal one of their few skills. Bosses have skills not found anywhere else though so you'll probably end up doing both these techniques. There are also some quests which reward you with extra skills, like in the tutorial area, so keep an eye out for those. In general, unless you are in an optional outpost, all skills found in towns can be quested for. Each time you acquire a skill, from whatever source, that skill becomes 'unlocked'. Unlocked skills can be picked by level 20 PVP exclusive characters.
Find the wilderness zone of your city and look for quests. For this, you should recruit a warrior and a monk npc (non player character) if you are a caster, or an elementalist and monk if you are a melee. Talk to the npcs in the wilderness zones as well as cities for quests. New quests become available as you complete old ones, or finish a new mission so always keep an eye out. The rewards for these quests vary but it is worth your time and they are also shorter than the missions.
Buy more bags. You can find these pretty early on. Bags allow you to carry more. Everyone wants more room for their stuff right? Well bags fufill that need. Economically speaking, you don't NEED more room unless you have to constantly leave items behind in missions and you do not salvage many items. If you are trying to get rich quick, ask yourself if you need more room. For everyone else, hurray for more inventory space! You can buy runes of holding to double the size of "bags" as well. There are collectors to get all your bags from as well but they might be too far for your patience.
Walk all the way to the other towns through the wilderness (advanced). This will allow you to have access to more markets for your goods, npc and player alike. You should do this with a group of players, preferably with some of them being much higher level than you so that they can deal with the more dangerous enemies you are bound to face. You can also find special crafters or merchants this way, or even additional quests!
On Your Own
After exiting the tutorial area, you can start your first mission which should get you enough resources to start building up trade resources. You can try selling the resources you do not need (I recommend waiting until you get to Lion's Arch, as you will get better prices there). Lion's Arch has a few extras that other towns do not have. You should keep any dyes you find for when you leave pre-searing Ascalon instead of using them early on, as they are a good source of money. Of course if players are buying, feel free to sell (if you can get a good price). You will lose any colours when you update your armour so you might as well wait. One you get a bit later into the game, or if you find a more advanced city through exploration, you can buy additional bags. Once you have a lot of carrying room, you can be more patient when selling which should give you better prices. This should start you off on the right foot; with that and smart trading you should not have any problems upgrading your armour as it becomes available. The upgrades are significant so I do not recommend skipping them.
*** This article was written by delicious_doctor and because it is interesting guide for all of newcomers in Tyria, I posted it here. :)